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The anticonvulsant drug gabapentin functions by regulating the activation of voltage-dependent calcium channels in neurons. It is believed that the mechanism of action involves blocking particular types of calcium channels in the brain, which helps to reduce pain and nerve impulses that might cause seizures. It has also been shown that gabapentin inhibits the release of neurotransmitters such as glutamate, substance P, and norepinephrine from sensory neurons.
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